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Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). It acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It does this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.
| Molecular Weight | 211.17 |
| Formula | C8H9N3O4 |
| CAS Number | 65141-46-0 |
| Solubility (25°C) | DMSO 30 mg/mL Water 18 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Hend Ashour, et al. Hypothesis: The potential therapeutic role of nicorandil in COVID-19
[4] Mustafa Karanfil, et al. Nicorandil and Contrast-Induced Nephropathy
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