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Niclosamide sodium

Cat. No. M38628

All AbMole products are for research use only, cannot be used for human consumption.

Niclosamide sodium Structure

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Biological Activity

Niclosamide (BAY2353) sodium is an orally active antihelminthic agent used in parasitic infection research. Niclosamide sodium is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide sodium has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.

Chemical Information
Molecular Weight 349.1
Formula C13H7Cl2N2NaO4
CAS Number 40321-86-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] V M Chaitra et al. Ann Pharm Fr. A simultaneous liquid chromatographic analysis of niclosamide and bicalutamide in rat plasma by protein precipitation extraction

[2] Yosuke Kato et al. J Biosci Bioeng. Niclosamide affects intracellular TDP-43 distribution in motor neurons, activates mitophagy, and attenuates morphological changes under stress

[3] XingGang He et al. Bioorg Chem. Discovery of degradable niclosamide derivatives able to specially inhibit small cell lung cancer (SCLC)

[4] Ali Al-Gareeb et al. Arch Rheumatol. The Anti-Rheumatoid Activity of Niclosamide in Collagen-Induced Arthritis in Rats

[5] So-Yeon Park et al. Clin Cancer Res. Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness

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