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NI 42 is a high affinity BRPF inhibitor (Kd values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (Kd = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.
| Molecular Weight | 353.39 |
| Formula | C18H15N3O3S |
| CAS Number | 1884640-99-6 |
| Solubility (25°C) | DMSO 17.67 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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