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NGI-1

Cat. No. M9829

All AbMole products are for research use only, cannot be used for human consumption.

NGI-1 Structure
Synonym:

ML414; NGI1

Size Price Availability Quantity
5mg USD 48 In stock
10mg USD 72 In stock
25mg USD 128 In stock
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Quality Control & Documentation
Biological Activity

NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation, which inhibits the oligosaccharyltransferase, preventing the attachment to the protein. NGI-1 induces senescence in receptor tyrosine kinase dependent tumors. NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed.

Chemical Information
Molecular Weight 394.51
Formula C17H22N4O3S2
CAS Number 790702-57-7
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shenglin Zhu, et al. J Virol. Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein

[2] Cecilia Lopez-Sambrooks, et al. Nat Chem Biol. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

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Keywords: NGI-1, ML414; NGI1 supplier, Anti-infection, inhibitors, activators

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