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NF-56-EJ40

Cat. No. M14741

All AbMole products are for research use only, cannot be used for human consumption.

NF-56-EJ40 Structure
Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 360  USD360 In stock
50mg USD 1240  USD1240 In stock
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Quality Control & Documentation
Biological Activity

NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.

Chemical Information
Molecular Weight 443.54
CAS Number 2380230-73-7
Form Solid
Solubility (25°C) DMSO 5 mg/mL
Water 4.55 mg/mL (ultrasonic and adjust pH to 9 with NaOH)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jingwen Xu, et al. Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis

[2] Matthias Haffke, et al. Structural basis of species-selective antagonist binding to the succinate receptor

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Keywords: NF-56-EJ40 supplier, inhibitors, activators

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