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Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer.
| Molecular Weight | 421.62 |
| Formula | C27H39N3O |
| CAS Number | 133825-80-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[4] Tao Long, et al. Nature. Structure of nevanimibe-bound tetrameric human ACAT1
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