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Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
| Molecular Weight | 503.39 |
| Formula | C18H26N10O3 · 2HCl |
| CAS Number | 18133-22-7 |
| Solubility (25°C) | Water: 1 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] M Bialer, et al. Antiparasitic structure-activity relationships of congocidine derivatives
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