Netilmicin Sulfate is an aminoglycoside antibiotic derived from actinomycetes that specifically binds to the 30S small subunit of the bacterial ribosome, interfering with bacterial protein synthesis, with excellent killing activity against gram-negative bacteria.
| Molecular Weight | 1441.55 |
| Formula | C21H41N5O7.2.5H2O4S |
| CAS Number | 56391-57-2 |
| Form | Solid |
| Solubility (25°C) | 288 mg/mL in water |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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