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Neobyakangelicol

Cat. No. M40284
Neobyakangelicol Structure
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Biological Activity

Neobyakangelicol is a natural product from Baizhi.

Chemical Information
Molecular Weight 316.31
Formula C17H16O6
CAS Number 35214-82-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] You-Bo Zhang et al. J Pharm Biomed Anal. Tissue distribution study of Angelica dahurica cv. Yubaizhi in rat by ultra-performance liquid chromatography with tandem mass spectrometry

[2] Gai-Gai Deng et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents from lipophilic parts in roots of Angelica dahurica cv.Yubaizhi]

[3] Ai-Hong Zhao et al. Phytomedicine. Simultaneous determination and pharmacokinetics of sixteen Angelicae dahurica coumarins in vivo by LC-ESI-MS/MS following oral delivery in rats

[4] Ping-ping Song et al. Zhong Yao Cai. [Chemical constituents of Angelica nitida roots]

[5] A C Adebajo et al. Fitoterapia. Minor furocoumarins of Murraya koenigii

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