Nedocromil has been shown to inhibit the in vitro activation of, and mediator release from, a variety of inflammatory cell types associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. Nedocromil inhibits activation and release of inflammatory mediators such as histamine, prostaglandin D2 and leukotrienes c4 from different types of cells in the lumen and mucosa of the bronchial tree. These mediators are derived from arachidonic acid metabolism through the lipoxygenase and cyclo-oxygenase pathways. The mechanism of action of nedocromil may be due partly to inhibition of axon reflexes and release of sensory neuropeptides, such as substance P, neurokinin A, and calcitonin-geneñrelated peptides. The result is inhibition of bradykinin-induced bronchoconstriction. Nedocromil does not posess any bronchodilator, antihistamine, or corticosteroid activity.
Molecular Weight | 371.34 |
Formula | C19H17NO7 |
CAS Number | 69049-73-6 |
Solubility (25°C) | DMSO 2 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] A V Sridhar, et al. Nedocromil sodium for chronic asthma in children
[2] C H Spooner, et al. Nedocromil sodium for preventing exercise-induced bronchoconstriction
[3] C H Spooner, et al. Nedocromil sodium for preventing exercise-induced bronchoconstriction
[4] S I Wasserman. Immunopharmacologic profile of nedocromil sodium
Related Histamine Receptor Products |
---|
Peptide 401
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT). |
Granuliberin R
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. |
Dimethindene maleate
Dimethindene maleate is a selective histamine H1 receptor antagonist with antihistamine activity.Dimethindene maleate may be used in studies related to allergic reactions. |
4-Methylhistamine
4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). |
H4R antagonist 3
H4R antagonist 3 is a histamine-4 receptor antagonist with an EC50 of <10 mM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.