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NDSB-201

Cat. No. M39649
NDSB-201 Structure
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Biological Activity

NDSB-201 consists of a pyridine group attached to a propane chain, which in turn is attached to a sulfonate group.

Chemical Information
Molecular Weight 201.24
Formula C8H11NO3S
CAS Number 15471-17-7
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kittikhun Wangkanont et al. Protein Expr Purif. The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain

[2] David J Leibly et al. PLoS One. Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins

[3] Adelson Joel da Silva et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. Purification, crystallization and preliminary crystallographic studies of SPCI-chymotrypsin complex at 2.8 A resolution

[4] Melissa Swope Willis et al. Protein Sci. Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactions

[5] Y Chong et al. Biotechniques. Preparation of functional recombinant protein from E. coli using a nondetergent sulfobetaine

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