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NDMC101

Cat. No. M8464

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NDMC101 Structure

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Quality Control & Documentation
Biological Activity

NDMC101 (HS Cm) is a potent dipeptidyl peptidase-IV (DPPIV) inhibitor in T cells with low cytotoxicity. NDMC101 is a potent immunomodulator that inhibits production of IL-2, TNF-α and IFN-γ. NDMC101 inhibits osteoclastogenesis in experimental model of arthritis.

Chemical Information
Molecular Weight 265.67
Formula C13H9ClFNO2
CAS Number 1308631-40-4
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chia-Chung Lee, et al. Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones

[2] Chia-Chung Lee, et al. Discovery of 5-(2',4'-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis

[3] Jun-Ting Liou, et al. A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells

[4] Chia-Pi Cheng, et al. A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis

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Keywords: NDMC101 supplier, inhibitors, activators

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