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NCGC00138783

Cat. No. M11439
NCGC00138783  Structure
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Quality Control
Biological Activity

NCGC00138783 selectively blocked the interaction of CD47/SIRPα with IC50 of 40 μM. NCGC00138783 does not disrupt the binding of CD47/SIRPα to other receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 731.64
Formula C30H28F7N7O5S
CAS Number
Purity
Solubility N/A
Storage at -20°C
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Antide

Sequence:Ac-D2Nal-DCpa-DPal-Ser-Lys(nicotinoyl)-DLys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-DAla-NH2

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  Catalog
Abmole Inhibitor Catalog




Keywords: NCGC00138783 supplier, inhibitors

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