Free shipping on all orders over $ 500

NBI 42902

Cat. No. M13419

All AbMole products are for research use only, cannot be used for human consumption.

NBI 42902 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

NBI-42902 is an effective inhibitor of peptide radioligand binding to human GnRH receptor (K(I)=0.56 nm). Tritiated NBI-42902 binds to a single class of binding sites with high affinity (K(d)=0.19 nm) and can be replaced by a range of peptide and non-peptide GnRH receptor ligands.

Chemical Information
Molecular Weight 495.49
Formula C27H24F3N3O3
CAS Number 352290-60-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Susan K Sullivan, et al. Biochemistry. Allosteric and orthosteric binding modes of two nonpeptide human gonadotropin-releasing hormone receptor antagonists

[2] R Scott Struthers, et al. Endocrinology. Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902

[3] Susan K Sullivan, et al. Biochem Pharmacol. Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism

[4] R Scott Struthers, et al. J Clin Endocrinol Metab. Suppression of serum luteinizing hormone in postmenopausal women by an orally administered nonpeptide antagonist of the gonadotropin-releasing hormone receptor (NBI-42902)

[5] Fabio C Tucci, et al. J Med Chem. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in䲧璵Ỵ璶㧀璴羹癦

Related Products
2-Deoxy-2-fluoro-D-glucose

2-Deoxy-2-fluoro-D-glucose is a radiolabeled glucose analog, which is commonly used in medical imaging techniques such as positron emission tomography (PET) scans.

2-Bromo-4-chlorophenylacetic acid

2-Bromo-4-chlorophenylacetic acid is a biochemical reagent.
CPN-351 TFA

CPN-351 TFA is a selective pentapeptide antagonist of human NMUR1 with a pA2 of 7.35. CPN-351 TFA can be used for the research of inflammation.
5-Phenyluracil

5-Phenyluracil is a pyrimidine derivative, a class of heterocyclic aromatic organic compounds crucial in biochemistry. It serves as a synthetic nucleoside analogue, meaning it mimics the structure of naturally occurring nucleosides like uridine. This structural similarity allows it to participate in biochemical reactions, often interfering with normal cellular processes, making it a valuable tool in studying nucleic acid metabolism and developing antiviral and anticancer agents.
7-Deoxyloganin

7-Deoxyloganin is a biosynthetic precursor of Loganin. 7-Deoxyloganin undergoes hydroxylation catalyzed by 7-deoxyloganin 7-hydroxylase, a cytochrome P450-dependent monooxygenase, to produce Loganin.
  Catalog
Abmole Inhibitor Catalog




Keywords: NBI 42902 supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.