Free shipping on all orders over $ 500

NBI 42902

Cat. No. M13419

All AbMole products are for research use only, cannot be used for human consumption.

NBI 42902 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

NBI-42902 is an effective inhibitor of peptide radioligand binding to human GnRH receptor (K(I)=0.56 nm). Tritiated NBI-42902 binds to a single class of binding sites with high affinity (K(d)=0.19 nm) and can be replaced by a range of peptide and non-peptide GnRH receptor ligands.

Chemical Information
Molecular Weight 495.49
Formula C27H24F3N3O3
CAS Number 352290-60-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Susan K Sullivan, et al. Biochemistry. Allosteric and orthosteric binding modes of two nonpeptide human gonadotropin-releasing hormone receptor antagonists

[2] R Scott Struthers, et al. Endocrinology. Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902

[3] Susan K Sullivan, et al. Biochem Pharmacol. Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism

[4] R Scott Struthers, et al. J Clin Endocrinol Metab. Suppression of serum luteinizing hormone in postmenopausal women by an orally administered nonpeptide antagonist of the gonadotropin-releasing hormone receptor (NBI-42902)

[5] Fabio C Tucci, et al. J Med Chem. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in䲧璵Ỵ璶㧀璴羹癦

Related Products
PCL-PEG-MAL

PCL-PEG-MAL is an amphiphilic block copolymer consisting of polycaprolactone (PCL), polyethylene glycol (PEG) and maleimide (MAL) functional groups. PCL-PEG-MAL is used in targeted delivery systems, surface modification of nanomaterials, functionalisation of biomaterials and biosensing technologies for specific chemical linkages or biomolecular immobilisation.

DSPE-PEG-Streptavidin

DSPE-PEG-Streptavidin is an important biocoupling molecule widely used in biomedical research, especially in drug delivery, targeted therapies, immunodiagnostics and biosensors. Through the specific binding between streptavidin and biotin, DSPE-PEG-Streptavidin can help to achieve efficient loading and targeted action in targeted delivery systems. In addition, the molecule is widely used in molecular imaging and bioassays, especially for molecular recognition using the strong affinity between streptavidin and biotin in assay platforms that require high sensitivity and specificity.

E7107

E7107 is a first-in-class precursor messenger ribonucleic acid (pre-mRNA) spliceosome inhibitor.

KL044

KL044 is a stabilizer of the clock protein cryptochrome (CRY). KL044 is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.

2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide

2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide is a biochemical material that can be used in scientific research.

  Catalog
Abmole Inhibitor Catalog




Keywords: NBI 42902 supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.