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NBD 556 is a cD4 mimetic (IC50 values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell lines, by blocking virus-cell and cell-cell fusion.
| Molecular Weight | 337.84 |
| Formula | C17H24ClN3O2 |
| CAS Number | 333353-44-9 |
| Solubility (25°C) | DMSO 33.78 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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