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NBD 556

Cat. No. M7019

All AbMole products are for research use only, cannot be used for human consumption.

NBD 556 Structure

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Quality Control & Documentation
Biological Activity

NBD 556 is a cD4 mimetic (IC50 values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell lines, by blocking virus-cell and cell-cell fusion.

Chemical Information
Molecular Weight 337.84
Formula C17H24ClN3O2
CAS Number 333353-44-9
Solubility (25°C) DMSO 33.78 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xiang, et al. ACS Chem Neurosci. The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease.

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Keywords: NBD 556 supplier, inhibitors, activators

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