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Naringin

Cat. No. M11528
Naringin Structure
Synonym:

Naringoside

Size Price Availability Quantity
200mg USD 60  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 580.53
Formula C27H32O14
CAS Number 10236-47-2
Purity >98%
Solubility DMSO ≥ 200 mg/mL
Storage 2-8°C
References

[1] Reza Heidary Moghaddam, et al. Eur J Pharmacol. Naringenin and naringin in cardiovascular disease prevention: A preclinical review

[2] Hui Zhao, et al. Biosci Rep. Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

[3] Salman Ahmed, et al. Food Chem Toxicol. Therapeutic potential of naringin in neurological disorders

[4] Hongyang Cao, et al. J Agric Food Chem. Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice

[5] Rui Chen, et al. Pharm Biol. Therapeutic potential of naringin: an overview

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Keywords: Naringin, Naringoside supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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