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Naphthol AS-E 

Cat. No. M30926

All AbMole products are for research use only, cannot be used for human consumption.

Naphthol AS-E  Structure

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Quality Control & Documentation
Biological Activity

Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 µM. Naphthol AS-E can be used for cancer research.

Chemical Information
Molecular Weight 297.74
Formula C17H12ClNO2
CAS Number 92-78-4
Form Solid
Solubility (25°C) DMSO 41.67 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Min Jiang, et al. J Cell Mol Med. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis

[2] Sagar Uttarkar, et al. Mol Cancer Ther. Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300

[3] Fuchun Xie, et al. Lett Org Chem. Synthesis and Evaluation of an O-Aminated Naphthol AS-E as a Prodrug of CREB-mediated Gene Transcription Inhibition

[4] Bingbing X Li, et al. Bioorg Med Chem. Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription

[5] Min Jiang, et al. J Med Chem. Design, synthesis, and biological evaluation of conformationally constrained analogues of naphthol AS-E as inhibitors of CREB-mediated gene transcription

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Keywords: Naphthol AS-E  supplier, Histone Acetyltransferase, inhibitors, activators

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