Nanchangmycin is an antiviral compound. Inhibition of Zika virus entry into a range of cell types, including primary placental fibroblasts, HUVECs and UtMECs (IC50 values of U2OS, HBMECs and JEG-3 cells were 0.1, 0.4 and 0.97 μM, respectively). It also inhibited cell uptake of West Nile virus, dengue fever, Sinderby virus and chikungunya virus.
|Solubility (25°C)||DMSO 88.91 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
AGX87 is a neurotyrosine kinase receptor (NTRK) inhibitor, as well as a proto-oncogene tyrosine protein kinase (ROS1) inhibitor, and may be used in studies related to solid tumors.
Palopegteriparatide is a long-acting precursor compound of parathyroid hormone (PTH), as well as a calcium-sensitive receptor (CaSR) antagonist, and a parathyroid hormone receptor (PTH1R) modulator, and may be used in studies related to hypoparathyroidism (HP).
Agarose is a low melting point agarose modified with hydroxyethyl and methoxy groups on the polysaccharide chain, which is suitable for in-gel enzymatic reactions, tissue culture, cell cloning and viral vacuole analysis and other related studies.
Al-3d directly binds to Aster-B and Aster-C proteins, thereby inhibiting cholesterol absorption.
yGsy2p-IN-H23 is a first-in-class, potent inhibitor of yeast glycogen synthase 2 (yGsy2p) that binds within the glucose-binding pocket of uridine diphosphate of yGsy2p, with an IC50 value of 875 µM for human glycogen synthase 1 (hGYS1). it can be used in studies related to glycogen accumulation diseases (GSDs).
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