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Cat. No. M7015
Nanchangmycin Structure

Nanchangmycin A

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Biological Activity

Nanchangmycin is an antiviral compound. Inhibition of Zika virus entry into a range of cell types, including primary placental fibroblasts, HUVECs and UtMECs (IC50 values of U2OS, HBMECs and JEG-3 cells were 0.1, 0.4 and 0.97 μM, respectively). It also inhibited cell uptake of West Nile virus, dengue fever, Sinderby virus and chikungunya virus.

Chemical Information
Molecular Weight 889.1
Formula C47H77NaO14
CAS Number 65101-87-3
Solubility (25°C) DMSO 88.91 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Fazio. Mol Pharmacol. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors.

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Keywords: Nanchangmycin, Nanchangmycin A supplier, inhibitors, activators

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