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Nalidixic acid sodium salt

Cat. No. M7963
Nalidixic acid sodium salt Structure
Size Price Availability Quantity
50mg USD 35  USD35 In stock
100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Nalidixic acid sodium salt is a quinolone antibiotic, it is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations.

Chemical Information
Molecular Weight 254.22
Formula C12H11N2NaO3
CAS Number 3374-05-8
Solubility (25°C) Water 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dana K Dittoe, et al. The Efficacy of Sodium Bisulfate Salt (SBS) Alone and Combined With Peracetic Acid (PAA) as an Antimicrobial on Whole Chicken Drumsticks Artificially Inoculated With Salmonella Enteritidis

[2] Brittney R Scott, et al. Antimicrobial Efficacy of a Sulfuric Acid and Sodium Sulfate Blend, Peroxyacetic Acid, and Cetylpyridinium Chloride against Salmonella on Inoculated Chicken Wings

[3] K Grlitzer, et al. Color reactions for identification of nalidixic acid

[4] R J Rowbury, et al. Sodium chloride induces an NhaA/NhaR-independent acid sensitivity at neutral external pH in Escherichia coli

[5] E Pawelczyk, et al. Analysis of the products of drug degradation. XXV. Spectrophotometric method of determination of the content of sodium salt of nalidixic acid (NA-Na)

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