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NAB2 

Cat. No. M28546

All AbMole products are for research use only, cannot be used for human consumption.

NAB2  Structure

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Quality Control & Documentation
Biological Activity

NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a agentgable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking.

Chemical Information
Molecular Weight 389.88
Formula C23H20ClN3O
CAS Number 1504588-00-4
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Edwin B Corgiat, et al. G3 (Bethesda). The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism

[2] Michael E Kallen, et al. Am J Surg Pathol. The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?

[3] Ye-Seul Park, et al. Biochem Biophys Res Commun. NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation

[4] Milo B Fasken, et al. Protein Sci. Structure-function relationships in the Nab2 polyadenosine-RNA binding Zn finger protein family

[5] Sayaka Yuzawa, et al. Am J Surg Pathol. Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature

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Keywords: NAB2  supplier, inhibitors, activators

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