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N-methyl-N-dithiocarboxyglucamine sodium

Cat. No. M42364
N-methyl-N-dithiocarboxyglucamine sodium Structure
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Biological Activity

N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound 109Cd in mouse model.

Chemical Information
Molecular Weight 293.34
Formula C8H16NNaO5S2
CAS Number 91840-27-6
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] L A Shinobu et al. Acta Pharmacol Toxicol (Copenh). Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication

[2] G R Gale et al. Life Sci. Effects of sodium N-methyl-N-dithiocarboxyglucamine on cadmium distribution and excretion

[3] S G Jones et al. J Toxicol Environ Health. The effect of zinc on the dithiocarbamate-induced mobilization of cadmium deposits in mice

[4] M M Jones et al. Arch Toxicol. Control of some aspects of cis-platinum nephrotoxicity

[5] P J Neveu et al. Int Arch Allergy Appl Immunol. Evaluation of the mechanisms involved in sodium diethyl dithiocarbamate-induced immunomodulation using the hydrophilic analog, sodium N-methyl-D-glucamine dithiocarbamate

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