Free shipping on all orders over $ 500

N-Hexanoyl-L-homoserine lactone

Cat. No. M11309
N-Hexanoyl-L-homoserine lactone Structure
Synonym:

C6-HSL

Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 310  USD310 In stock
25mg USD 600  USD600 In stock
50mg USD 900  USD900 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

N-hexanoyl-l-homoserine lactone is a short-chain N-acyl-homoserine lactone (AHL). AHL is an intercellular communication signal molecule in the quorum-sensing system of Gram-negative bacteria and mediates information exchange between eukaryotic plants and prokaryotic bacteria.

Chemical Information
Molecular Weight 199.25
Formula C10H17NO3
CAS Number 147852-83-3
Form Solid
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yupeng Zhang, et al. Bioresour Technol. Exogenous N-hexanoyl-L-homoserine lactone assists in upflow anaerobic sludge blanket recovery from acetate accumulation via aceticlastic methanogens enrichment

[2] Yang Yang, et al. Arch Microbiol. Quorum sensing-1 signaling of N-hexanoyl-L-homoserine lactone contributes to virulence in avian pathogenic Escherichia coli

[3] Olena V Moshynets, et al. PLoS One. Priming winter wheat seeds with the bacterial quorum sensing signal N-hexanoyl-L-homoserine lactone (C6-HSL) shows potential to improve plant growth and seed yield

[4] Gopalakrishnan Vinoj, et al. Fish Shellfish Immunol. N-hexanoyl-L-homoserine lactone-degrading Pseudomonas aeruginosa PsDAHP1 protects zebrafish against Vibrio parahaemolyticus infection

[5] Catharine A Ortori, et al. Anal Bioanal Chem. Simultaneous quantitative profiling of N-acyl-L-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS

Related Antibiotic Products
TH-Z145

TH-Z145 is a lipophilic GGPPS inhibitor (GGPPS IC50 = 210 nM). TH-Z145 is a very lipophilic bisphosphonate that lacks the cationic center essential for FPPS inhibition and is thus a specific GGPPS inhibitor (FPPS IC50 >30 mM). TH-Z145 exhibited strong prophylactic effects in a pathogenic influenza model.
TH-Z93

TH-Z93, a lipophilic bisphosphonate, is an FPPS inhibitor (IC50 = 90 nM). TH-Z93 exhibits potent efficacy, increasing both antibody titers and avidity. TH-Z93 exhibited strong prophylactic effects in a pathogenic influenza model.
Ningnanmycin

Ningnanmycin is a cytosine nucleoside peptide antibiotic, which is a highly effective, low-toxic, non-accumulative, broad-spectrum fungicide.
Sulfacytine

Sulfacytine is a short-acting sulfonamide antibiotic.
Cefcapene pivoxil hydrochloride

Cefcapene pivoxil hydrochloride, the pivalate ester precursor form of Cefcapene, is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) research.
  Catalog
Abmole Inhibitor Catalog




Keywords: N-Hexanoyl-L-homoserine lactone , C6-HSL supplier, Antibiotic, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.