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N-Desethyl Sunitinib is a major and pharmacologically active metabolite of the tyrosine kinase inhibitor and anticancer compound Sunitinib. Sunitinib also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib exhibits antiangiogenic and antitumor activity in multiple xenograft models.
| Molecular Weight | 370.42 |
| Formula | C20H23FN4O2 |
| CAS Number | 356068-97-8 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| p-Cresol glucuronide
p-Cresol glucuronide is a metabolite of p-cresol, it is a prototype protein-bound uremic toxin. |
| Oleamide
Oleamide is an endogenous fatty acid amide. |
| Deoxycarnitine chloride
Deoxycarnitine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota. |
| Monobutyl phthalate
Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant. |
| Testosterone sulfate (pyridinium)
Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. |
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