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N-5984

Cat. No. M29347
N-5984 Structure
Synonym:

KRP-204

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Biological Activity

N-5984 (KRP-204) is a potent and selective agonist of β3-adrenergic receptor. N-5984 has the potential for developing as one of the clinically effective drugs for obesity and diabetes mellitus.

Chemical Information
Molecular Weight 391.85
Formula C20H22ClNO5
CAS Number 220475-76-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Emily G Hurley, et al. Womens Health Rep (New Rochelle). Minimal Stimulation Using Gonadotropin-Releasing Hormone Antagonist is Associated with Higher Live Birth Rates: A National Study of 13,050 Cycles

[2] Samantha Bui, et al. Vet Anim Sci. Warm water treatment increased mortality risk in salmon

[3] Kristian Bundgaard Ringgren, et al. BMC Emerg Med. Mortality and return to work in patients transported by emergency ambulance after involvement in a traffic accident

[4] Kevin M Beaver, et al. Arch Sex Behav. Sexual Orientation and Involvement in Nonviolent and Violent Delinquent Behaviors: Findings From the National Longitudinal Study of Adolescent to Adult Health

[5] T Yanagisawa, et al. Tohoku J Exp Med. Selectivity and potency of agonists for the three subtypes of cloned human beta-adrenoceptors expressed in Chinese hamster ovary cells

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Keywords: N-5984, KRP-204 supplier, Adrenergic Receptor, inhibitors, activators

 
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