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N-[(4-Aminophenyl)methyl]adenosine

Cat. No. M30970
N-[(4-Aminophenyl)methyl]adenosine Structure
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Biological Activity

N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase. IC50 value: 29.0 ± 1.7 nM (Ki) Target: Adenosine Receptor

Chemical Information
Molecular Weight 372.38
Formula C17H20N6O4
CAS Number 95523-13-0
Form Solid
Solubility (25°C) DMSO 10 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shu-Chun Peng, et al. Eur J Pharmacol. The role of intraspinal adenosine A1 receptors in sympathetic regulation

[2] G De Sarro, et al. Eur J Pharmacol. Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice

[3] M P Abbracchio, et al. Mol Pharmacol. G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain

[4] W W Barrington, et al. Proc Natl Acad Sci U S A. Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking

[5] Q Y Zhou, et al. Proc Natl Acad Sci U S A. Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor

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Keywords: N-[(4-Aminophenyl)methyl]adenosine supplier, Adenosine Receptor, inhibitors, activators

 
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