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Myristic acid

Cat. No. M10448
Myristic acid Structure
Size Price Availability Quantity
5g USD 40  USD40 In stock
10g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.

Chemical Information
Molecular Weight 228.37
Formula C14H28O2
CAS Number 544-63-8
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kai Iwata, et al. Biochim Biophys Acta Mol Cell Biol Lipids. Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells

[2] Tamae Takato, et al. Diabetologia. Chronic administration of myristic acid improves hyperglycaemia in the Nagoya-Shibata-Yasuda mouse model of congenital type 2 diabetes

[3] Emma Kummrow, et al. J Lipid Res. Myristic acid increases dense lipoprotein secretion by inhibiting apoB degradation and triglyceride recruitment

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