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Myclobutanil

Cat. No. M20526
Myclobutanil Structure
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Biological Activity

Myclobutanil is a conazole class fungicide widely used as an agrichemical.

Chemical Information
Molecular Weight 288.78
Formula C15H17ClN4
CAS Number 88671-89-0
Solubility (25°C) DMSO 58 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rulaiha Taylor, et al. Toxicol Sci. Myclobutanil Mediated Alteration of Liver-Gut FXR Signaling in Mice

[2] Yanli Qi, et al. Se Pu. [Determination of myclobutanil enantiomers in wheat and its processed products by ultraperformance liquid chromatography-tandem mass spectrometry based on a chiral stationary phase]

[3] Laura Cordero-Limon, et al. Pest Manag Sci. Cross-resistance between myclobutanil and tebuconazole and the genetic basis of tebuconazole resistance in Venturia inaequalis

[4] Franciele S Fonseca, et al. Food Chem Toxicol. Myclobutanil enantioselective risk assessment in humans through in vitro CYP450 reactions: Metabolism and inhibition studies

[5] Chunmian Lin, et al. Environ Sci Pollut Res Int. Enantioselective degradation of Myclobutanil and Famoxadone in grape

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