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Murlentamab

Cat. No. M24896

All AbMole products are for research use only, cannot be used for human consumption.

Murlentamab Structure
Synonym:

3C23K GM102

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Quality Control & Documentation
Biological Activity

Murlentamab (3C23K; GM102) is a humanized anti-AMHRII antibody. AMHRII is the anti-Müllerian hormone receptor. Murlentama significantly promotes macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Murlentama stimulates pro-inflammatory and anti-tumor internal environment, recruits and activates T cells. Murlentama suppresses tumors growth by inducing naïve macrophage orientation and promoting tumor-associated macrophage (TAM) reprogramming.

Chemical Information
CAS Number 2058047-65-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Olga Dubová, et al. Ceska Gynekol. Anti-Müllerian hormone - clinical use and future possibilities

[2] Mélissa Prat, et al. Cancers (Basel). Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation

[3] Jean-Marc Barret, et al. Biology (Basel). The Expression of Anti-Müllerian Hormone Type II Receptor (AMHRII) in Non-Gynecological Solid Tumors Offers Potential for Broad Therapeutic Intervention in Cancer

[4] Mélissa Prat, et al. J Immunother Cancer. Circulating CD14high CD16low intermediate blood monocytes as a biomarker of ascites immune status and ovarian cancer progression

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Keywords: Murlentamab, 3C23K GM102 supplier, inhibitors, activators

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