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MTK458

Cat. No. M45064

All AbMole products are for research use only, cannot be used for human consumption.

MTK458 Structure
Synonym:

EP-0035985

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 138  USD138 In stock
25mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

MTK458 is an orally active, brain-permeable PINK1 activator that binds to and stabilizes the active isoform of PINK1, thereby enhancing mitophagy and promoting mitochondrial autophagy (Mitophagy). It can be used in studies related to Parkinson's disease (PD).

Chemical Information
Molecular Weight 332.32
Formula C17H15F3N4
CAS Number 2499962-58-0
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage 4°C, dry, sealed
References

[1] Nicholas Hertz, et al. Res Sq. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models

[2] Randall M Chin, et al. bioRxiv. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models

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  Catalog
Abmole Inhibitor Catalog




Keywords: MTK458, EP-0035985 supplier, inhibitors, activators

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