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MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2. LC-2 is a potent, first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50, between 0.25 and 0.76 μM).
| Molecular Weight | 720.23 |
| Formula | C37H43ClFN7O5 |
| CAS Number | 2561529-98-2 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PROTAC Linker Products |
|---|
| m-PEG2-acid
m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
| HO-PEG14-OH
HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| NH2-PEG3-C2-Boc
NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| NH2-PEG3-C1-Boc
NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
| Amino-PEG9-amine
Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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