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MRS 1754

Cat. No. M13884
MRS 1754 Structure
Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 205  USD205 In stock
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Quality Control & Documentation
Biological Activity

MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats.

Chemical Information
Molecular Weight 486.52
CAS Number 264622-58-4
Solubility (25°C) DMSO 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Roco Salsoso, et al. Insulin requires A 2B adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia

[2] Nils Ludwig, et al. Adenosine receptors regulate exosome production

[3] Veronica Della Latta, et al. The role of the adenosinergic system in lung fibrosis

[4] Rao V Kalla, et al. Recent developments in A2B adenosine receptor ligands

[5] X Ji, et al. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors

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