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MRL-494 

Cat. No. M29636

All AbMole products are for research use only, cannot be used for human consumption.

MRL-494  Structure

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Quality Control & Documentation
Biological Activity

MRL-494, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias.

Chemical Information
Molecular Weight 622.66
Formula C26H35FN16O2
CAS Number 2434898-43-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Nicola Wade, et al. ACS Infect Dis. Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494

[2] Janine H Peterson, et al. mBio. Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

[3] Elizabeth M Hart, et al. Proc Natl Acad Sci U S A. A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

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Keywords: MRL-494  supplier, Antibiotic, inhibitors, activators

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