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MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor.
| Molecular Weight | 359.37 |
| Formula | C18H19F2N5O |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Salt-inducible Kinase Products |
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| SIKs-IN-1
SIKs-IN-1 inhibitor. |
| SIK2-IN-1
SIK2-IN-1 is a potent SIK2 inhibitor over other AMPK kinases. |
| GLPG3970
GLPG3970 is a first-in-class salt-inducible kinase SIK2/SIK3 inhibitor for studies related to inflammatory and autoimmune diseases such as psoriasis. |
| YKL-06-062
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively. |
| MRT199665
MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370. |
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