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Mps BAY 2a is a potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
| Molecular Weight | 476.57 |
| Formula | C29H28N6O |
| CAS Number | 1382477-96-4 |
| Solubility (25°C) | DMSO 47.66 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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