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Monalizumab

Cat. No. M21501

All AbMole products are for research use only, cannot be used for human consumption.

Monalizumab  Structure
Synonym:

IPH2201

Size Price Availability Quantity
1mg USD 490  USD490 In stock
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Quality Control & Documentation
Biological Activity

Monalizumab is a first-in-class immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab is a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used in the study of head and neck squamous cell carcinoma (HNSCC).

Chemical Information
CAS Number 1228763-95-8
Form Liquid
Storage Store at -80°C for 2 years. Avoid multiple freeze-thaws.
References

[1] Jeongjae Lee, et al. J Cancer Res Clin Oncol. Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines

[2] Linda Borst, et al. Clin Cancer Res. The NKG2A-HLA-E Axis as a Novel Checkpoint in the Tumor Microenvironment

[3] Thorbald van Hall, et al. J Immunother Cancer. Monalizumab: inhibiting the novel immune checkpoint NKG2A

[4] Pascale Andr, et al. Cell. Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

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Keywords: Monalizumab , IPH2201 supplier, Checkpoint, inhibitors, activators

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