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MOMIPP 

Cat. No. M25548
MOMIPP  Structure
Size Price Availability Quantity
5mg USD 290  USD290 In stock
10mg USD 460  USD460 In stock
25mg USD 860  USD860 In stock
50mg USD 1280  USD1280 In stock
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Quality Control & Documentation
Biological Activity

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).

Chemical Information
Molecular Weight 292.33
Formula C18H16N2O2
CAS Number 1363421-46-8
Form Solid
Solubility (25°C) DMSO 20 mg/mL (ultrasonic and warming)
Storage Powder -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Frank Oppong, et al. J Pharm Sci. Investigating the Potential to Deliver and Maintain Plasma and Brain Levels of a Novel Practically Insoluble Methuosis Inducing Anticancer Agent 5-Methoxy MOMIPP Through an Injectable In Situ Forming Thermoresponsive Hydrogel Formulation

[2] Zehui Li, et al. BMC Cancer. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

[3] Shengnan Du, et al. Cancer Chemother Pharmacol. 6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability

[4] Nneka E Mbah, et al. Cell Biol Toxicol. Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones

[5] Christopher J Trabbic, et al. ACS Med Chem Lett. Differential Induction of Cytoplasmic Vacuolization and Methuosis by Novel 2-Indolyl-Substituted Pyridinylpropenones

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Keywords: MOMIPP  supplier, PI3K, inhibitors, activators


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