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Mobocertinib

Cat. No. M9535

All AbMole products are for research use only, cannot be used for human consumption.

Mobocertinib Structure
Synonym:

TAK-788; AP32788

Size Price Availability Quantity
Sample (0.5-1 mg)  USD 0 In stock
5mg USD 35  USD35 In stock
10mg USD 45  USD45 In stock
25mg USD 85  USD85 In stock
50mg USD 135  USD135 In stock
100mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

Mobocertinib (TAK-788) is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions. Mobocertinib (TAK-788) inhibits all 14 mutant variants of EGFR (IC50s=2.4-22 nM), and all 6 mutant variants of HER2 (IC50s=2.4-26 nM), more potently than it inhibited WT EGFR (IC50=35 nM). Daily oral dosing of Mobocertinib in mice implanted with a patient-derived tumor containing an EGFR exon 20 activating insertion induced regression of tumors at doses that were well tolerated (30-100 mg/kg).

*This compound is unstable in solutions, freshly prepared is recommended.

Chemical Information
Molecular Weight 585.70
Formula C32H39N7O4
CAS Number 1847461-43-1
Solubility (25°C) DMSO ≥ 8 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ashiq Masood, et al. Semin Oncol. Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: Focus on Afatinib.

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  Catalog
Abmole Inhibitor Catalog




Keywords: Mobocertinib, TAK-788; AP32788 supplier, EGFR/HER2, inhibitors, activators

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