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MMI-0100 is a novel cell permeant peptide inhibitor of Mitogen Activated Protein Kinase Activated Protein Kinase II (MK2), MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease. MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 caused sodium nitroprusside induced smooth muscle cell relaxation and inhibited intimal thickening in human saphenous vein rings in a dose-dependent fashion.
In a murine aortic bypass model, MMI-0100 reduced intimal thickness in vein grafts by 72%, and there were fewer F4/80-reactive cells in vein grafts treated with MMI-0100. MMI-0100 prevents vein graft intimal thickening ex vivo and in vivo.
| Molecular Weight | 2283.64 |
| Formula | C98H171N37O26 |
| CAS Number | 1039342-24-9 |
| Solubility (25°C) | Water ≥ 70 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
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