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ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity.
| Molecular Weight | 419.74 |
| Formula | C20H20BrClN2O |
| CAS Number | 1597489-14-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 10.42 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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