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Cat. No. M9719
ML367 Structure
Size Price Availability
5mg USD 450  USD450 4-7 Days
10mg USD 747  USD747 4-7 Days
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Quality Control & Documentation
Biological Activity

ML367 is an inhibitor of ATAD5 stabilization. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Chemical Information
Molecular Weight 334.32
Formula C19H12F2N4
CAS Number 381168-77-0
Solubility (25°C) DMSO ≥ 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jason M. Rohde, et al. Probe Reports from the NIH Molecular Libraries Program. Discovery of ML367, inhibitor of ATAD5 stabilization

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Keywords: ML367 supplier, ATPase, inhibitors, activators

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