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ML-7 hydrochloride

Cat. No. M7577

All AbMole products are for research use only, cannot be used for human consumption.

ML-7 hydrochloride  Structure
Synonym:

ML-7 HCl

Size Price Availability Quantity
1mg USD 20  USD20 In stock
5mg USD 50  USD50 In stock
10mg USD 75  USD75 In stock
25mg USD 140  USD140 In stock
50mg USD 210  USD210 In stock
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Quality Control & Documentation
Biological Activity

In vitro: ML-7 hydrochloride inhibits rabbit portal vein α1-adrenoceptor NSCC with IC50 of 0.8 μM. The myosin light chain kinase (MLCK) inhibitor ML-7 hydrochloride (3 μ M and 10 μM) also attenuates the Dexmedetomidine (DMT)-induced contraction (p<0.05 versus control).

In vivo: In sham operated animals Evans Blue extravasation is not different between ML-7 hydrochloride and vehicle group (sham+vehicle: 0.26±0.02 OD/g; sham+ML-7: 0.26±0.02 OD/g). After CCI inhibition of MLCK with ML-7 results in a significant lower amount of intracerebral Evans Blue compared to vehicle treated animals (CCI+vehicle: 0.42±0.04 OD/g; CCI+ML-7: 0.35±0.05 OD/g, p=0.048)

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines MCF-10A cells, MDCK cells
Preparation method Cells are treated with vehicle alone, Blebbistatin, ML-7, ML-9, latrunculin A or Y-27632 in media without serum at varying concentrations and time points before being fixed or prepared for FACS analysis. Untreated cells are also serum starved for the duration of the inhibitor treatment. Stock solutions of each agent are made in DMSO (50 μM Blebbistatin, 5 mM LA), 50% ethanol (10 mM ML-7), 70% ethanol (20 mM ML-9) or water (20 mM Y-27632) and are maintained at -20°C.
Concentrations 40 μM
Incubation time 16 h
Animal Experiment
Animal models Mice
Formulation distilled water
Dosages 1 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 452.74
Formula C15H18ClIN2O2S
CAS Number 110448-33-4
Solubility (25°C) DMSO 40 mg/mL
Water 1 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kwon Y, et al. Lab Invest. Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone.

[2] Kwon SR, et al, Oper Dent. Effect of Bleaching Gel Viscosity on Tooth Whitening Efficacy and Pulp Chamber Penetration: An In Vitro Study.

[3] Connell LE, et al. J Cell Sci. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.

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Keywords: ML-7 hydrochloride , ML-7 HCl supplier, inhibitors, activators

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