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MKT 077 is a occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.
| Molecular Weight | 432 |
| Formula | C21H22ClN3OS2 |
| CAS Number | 147366-41-4 |
| Solubility (25°C) | DMSO 21.6 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Macaluso, et al. ChemMedChem. Discovery of a competitive apelin receptor (APJ) antagonist.
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