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MK-6884

Cat. No. M21257

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MK-6884 Structure

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Quality Control & Documentation
Biological Activity

MK-6884 is an M4 muscarinic receptor orthomodulator (PAM) with a Ki value of 0.19 nM. MK-6884 is used in the study of neurodegenerative diseases. MK-6884 can be used as a positron emission computed tomography imaging agent with 11C radiolabeling.

Chemical Information
Molecular Weight 411.50
Formula C25H25N5O
CAS Number 2102194-04-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wenping Li, et al. Sci Transl Med. The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease

[2] Ling Tong, et al. J Med Chem. Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases

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Keywords: MK-6884 supplier, inhibitors, activators

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