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MK-0941 

Cat. No. M27831

All AbMole products are for research use only, cannot be used for human consumption.

MK-0941  Structure

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Quality Control & Documentation
Biological Activity

MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes.

Chemical Information
Molecular Weight 556.61
Formula C22H28N4O9S2
CAS Number 1137916-97-2
Form Solid
Solubility (25°C) DMSO 260 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
References

[1] Yoshinori Tsumura, et al. PLoS One. Disruptions in hepatic glucose metabolism are involved in the diminished efficacy after chronic treatment with glucokinase activator

[2] Filippos Kesisoglou, et al. AAPS J. Comparison of Deconvolution-Based and Absorption Modeling IVIVC for Extended Release Formulations of a BCS III Drυg Development Candidate

[3] Jun-ichi Eiki, et al. Mol Pharmacol. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs

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MK-0941 free base 

MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
  Catalog
Abmole Inhibitor Catalog




Keywords: MK-0941  supplier, Glucokinase (GK), inhibitors, activators

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