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MK-0773

Cat. No. M14619
MK-0773 Structure
Synonym:

PF-05314882

Size Price Availability
5mg USD 232  USD232 4-7 Days
10mg USD 353  USD353 4-7 Days
50mg USD 837  USD837 4-7 Days
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Quality Control & Documentation
Biological Activity

MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.

Chemical Information
Molecular Weight 479.59
CAS Number 606101-58-0
Solubility (25°C) DMSO 33.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Laurie Gheddar, et al. Development and validation of SARMs and metabolic modulators screening in hair using UHPLC-MS/MS: Application to a doping case and first identification of S23 in authentic human hair

[2] Mario Thevis, et al. Detection of SARMs in doping control analysis

[3] Andreas Lagojda, et al. Identification of selected in vitro generated phase-I metabolites of the steroidal selective androgen receptor modulator MK-0773 for doping control purposes

[4] D A Papanicolaou, et al. A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia

[5] Azriel Schmidt, et al. Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology

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  Catalog
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Keywords: MK-0773, PF-05314882 supplier, Androgen Receptor, inhibitors, activators


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