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Levamisole hydrochloride is an inhibitor of alkaline phosphatase, used as an anthelmintic. Levamisole hydrochloride has antiviral effects against HSV.
In vitro: L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells.
In vivo: Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay.
| Molecular Weight | 240.75 |
| Formula | C11H12N2S.HCl |
| CAS Number | 16595-80-5 |
| Solubility (25°C) | Water 48 mg/mL DMSO 10 mg/mL Ethanol 10 mg/mL |
| Storage | 4°C, dry, sealed |
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