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(-)-Curine

Cat. No. M38968

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(-)-Curine Structure

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Quality Control & Documentation
Biological Activity

(-)-Curine is an orally active bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum. (-)-Curine presents anti-inflammatory and analgesic effects at nontoxic doses, at least in part, resulting from the inhibition of prostaglandin E2 production.

Chemical Information
Molecular Weight 594.7
Formula C36H38N2O6
CAS Number 436-05-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jaime Ribeiro-Filho et al. Toxins (Basel). Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of Lipopolysaccharide-Induced Inflammation

[2] Jaime Ribeiro-Filho et al. Molecules. Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid

[3] Fagner Carvalho Leite et al. Planta Med. Curine, an alkaloid isolated from Chondrodendron platyphyllum inhibits prostaglandin E2 in experimental models of inflammation and pain

[4] Jaime Ribeiro-Filho et al. J Ethnopharmacol. Curine inhibits mast cell-dependent responses in mice

[5] Jaime Ribeiro-Filho et al. Toxicol Appl Pharmacol. Curine inhibits eosinophil activation and airway hyper-responsiveness in a mouse model of allergic asthma

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Keywords: (-)-Curine supplier, Prostaglandin Receptor, inhibitors, activators

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