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Mildronate (Meldonium) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes.
| Molecular Weight | 146.19 |
| CAS Number | 76144-81-5 |
| Solubility (25°C) | Water 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Nikolajs Sjakste, et al. Mildronate: an antiischemic drug for neurological indications
[5] Maija Dambrova, et al. Mildronate: cardioprotective action through carnitine-lowering effect
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