MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).
| Molecular Weight | 284.35 |
| Formula | C13H24N4O3 |
| CAS Number | 2002-44-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Rudolph H Ehrensing. Peptides. An extraordinary relationship involving MIF-1 and other peptides
[2] Weihong Pan, et al. Peptides. From MIF-1 to endomorphin: the Tyr-MIF-1 family of peptides
[3] G W Reed, et al. Neurosci Biobehav Rev. The Tyr-MIF-1 family of peptides
[4] Z H Galina, et al. Life Sci. Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1
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