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MI-4F is mesoionic compound that exhibits potent anticancer activity against multiple cancer cell lines and in vivo. MI-4F induces apoptosis in HepG2 cells. MI-4F appears to inhibit calcium efflux through inhibition formation of mitochondrial permeability transition pore (MPTP). MI-4F inhibits superoxide dismutase. MI-4F is not susceptible to MDR transporters P-glycoprotein, ABCG2 and MRP1. MI-4F also inhibits ABCG2-mediated efflux of mitoxantrone.
| Molecular Weight | 409.91 |
| Formula | C22H17ClFN3S |
| CAS Number | 346460-45-5 |
| Solubility (25°C) | DMSO: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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